New research indicates that individuals who discontinue new slimming jabs like semaglutide or tirzepatide can put back on shed pounds at a significantly accelerated pace than those who stop conventional lifestyle regimens.
Research printed in a prominent medical journal shows that while overweight people frequently drop substantial amounts of their body weight while on the medication, the mass comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"Individuals buying these treatments should be aware of the risk of rapid rebound weight gain when the medication ends," cautioned expert Dr. Susan Jebb.
That rate of regain means a reversion to pre-treatment weight in about a year and a half.
Comparing Treatments
The research, which examined 37 of studies involving thousands of participants, compared the outcomes of the injectable medications with older methods.
Researchers point out that people who lose weight through lifestyle changes alone usually see a slower creep back—around 0.1 kg a month—post-intervention.
Explaining the Quick Regain
Doctors propose the way of the injections explains the accelerated rebound.
The injections imitate a natural hormone called GLP-1, which helps regulate hunger.
"Artificially providing the hormone levels far above than the body's typical production might result in the system to produce less of its endogenous hormone, and may also diminish responsiveness to its actions," said Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this GLP-1 'fix' means hunger is no longer kept in check, making binge eating far more likely."
A Chronic Issue?
The NHS suggest the jabs for individuals with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
Many experts argue that, given the high risk of relapse, the therapy should be considered long-term.
This perspective is supported by drug manufacturers, who state that the findings "highlight the long-term character of obesity," similar to managing diseases like high blood pressure.
Patient Testimonies
People who have stopped the medication describe a powerful return of cravings.
"It felt as if something flipping and you become ravenous," said a patient.
The struggle is compounded if users have not adopted permanent lifestyle or habit modifications during treatment.
Significant Adoption
Figures show that millions of people in the UK have used weight-loss jabs in the last 12 months, with interest being substantial.
- Use is higher among women than men.
- The 40s and 50s demographic shows the highest usage rates.
- Many access the drugs through private healthcare rather than public health services.
Ultimately, experts caution that while GLP-1 drugs are effective agents for shedding pounds, they are not a permanent cure and long-term success likely depends on ongoing lifestyle support.
